Initial T cell frequency dictates memory CD8+ T cell lineage commitment
نویسندگان
چکیده
منابع مشابه
T-Cell Development: T-cell lineage commitment revisited
Years of controversy about the lineage relationship between alpha beta and gamma delta T cells may at last have been resolved: it now appears that most T cells derive from an identical T-lineage committed precursor.
متن کاملT cell lineage commitment: identity and renunciation.
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterward. This process involves three levels of regulatory change, in which the cells' intrinsic transcriptional regulatory factors, expression of signaling receptors (e.g., Notch1), and expression of distinct homi...
متن کاملT cell lineage commitment: identity and renunciation1
Precursors undertaking T-cell development shed their access to other pathways in a sequential process that begins before entry into the thymus and continues through many cell cycles afterwards. This process involves three levels of regulatory change, in which the cells’ intrinsic transcriptional regulatory factors, expression of signaling receptors like Notch1, and expression of distinct homing...
متن کاملVisualization of CD4/CD8 T Cell Commitment
A system to innocuously visualize T cell lineage commitment is described. Using a "knock-in" approach, we have generated mice expressing a beta-galactosidase reporter in place of CD4; expression of beta-galactosidase in these animals appears to be an accurate and early indicator of CD4 gene transcription. We have exploited this knock-in line to trace CD4/CD8 lineage commitment in the thymus, av...
متن کاملRestricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.
The molecular mechanisms regulating lymphocyte lineage commitment remain poorly characterized. To explore the role of the IL7R in this process, we generated transgenic mice that express a constitutively active form of STAT5 (STAT5b-CA), a key downstream IL7R effector, throughout lymphocyte development. STAT5b-CA mice exhibit a 40-fold increase in pro-B cells in the thymus. As documented by BrdU...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2005
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni1227